Cannabinoids (CBD) have been used medicinally for centuries, and in the last decade, attention has been focused on their broad therapeutic potential, especially in controlling seizures. Over the past 60 years, experimental studies have shown the anticonvulsant properties of CBD oil in several laboratory and natural experiments. To find out which CBD oil is best for epilepsy, let’s firstly get more in-depth into specific properties of one.
The discovery of type 1 cannabinoid receptors (CB1) has prompted many scientific studies that have discovered a compound, distinct signal system called the endocannabinoid system of the brain (ECS), a complex of the receptor system in space and time involved in continuous regulation / fine-tuning of the synaptic transmission. An increase in the threshold of neuronal sensitivity is the result of forced synthesis and release of endocannabinoid anandamides or 2-arachidonoyl glycerol, which retrogradely activates the presynaptic part of CB1 and then is rapidly excreted by the capture/degradation mechanism. Activation of CB1 can lead to both inhibition of protein kinase activity and induction of mitogen-activated protein / extracellular regulated kinase to modulate many subsequent cellular processes and transcription factors. In addition, inhibition of adenylate cyclase-induced cAMP production and activation of protein kinase A, inhibition of voltage-gated Ca2 + channels, and activation of K + channels act as the primary mechanisms underlying the on-demand regulation of synaptic transmission by inhibiting the vesicular release of neurotransmitters. It is the damping of excessive synaptic transmission by ECS, which underlies its function of regulating excitation and suppressing synaptic transmission.
ECS is distributed throughout the nervous system, emphasizing its role in regulating both physiological and pathophysiological synaptic transmission. In both experimental and clinical epilepsy, ECS brain plasticity is caused by a prolonged redistribution of the forebrain CB1, which can function as a compensatory adaptation to control neuronal excitability.
To discover the best CBD for seizures, check out the following.
CBD Oil For Epilepsy Reviews
Joy Organics CBD Oil Tincture
Short Brand Review
How do you know what CBD oil is best for epilepsy? One of the useful markers is that the company which offers the products is a member of the U.S. Hemp Roundtable. Joy Organics is in a coalition of a top world’s CBD oil brands, the purpose of which is to provide safe cannabis to the vast range of people. The company is a family business of people devoted to professionalism. Here, at Joy Organics, the best CBD product for epilepsy delivered from a seven-stages process: from top-tier farming through CO2 extraction and THC removing to the high-level laboratory tests. But what’s the most important, it contains MCT oil, which helps with Epilepsy, Autism, and Alzheimer’s. On top of that, the brand offers a variety of four flavors, which, in turn, gives it extra points. Depending on your preferences, you may choose between natural, mint, orange, or lemon.
- All-natural CBD oil
- Verified and approved
- May be considered as pricey
- Takes time before the effect kicks in
The product comes in four potencies: 225 mg, 450 mg, 900 mg, 1350 mg. The price tag varies accordingly from $29,95 to $99,95. “Over-the-budget” impression flatten by free shipping and delivery. And a cherry on a pie of every similar offer is a 30-day guarantee with a total refund.
Admittedly, it can’t cure epilepsy completely, but it is undoubtedly one of the best CBD oil for seizures. Thanks to CBD extracted from marijuana, the substance impacts the ECS, from what brain activity benefits. The amount and severity of the seizures will reduce. The risk of heart disease will also scale down. The amount and severity of the seizures will reduce. The risk of heart disease will also scale down. Taking it on a regular basis improves the effect.
NuLeaf Naturals Full-Spectrum CBD Oil
Short Brand Review
Looking through reviews of CBD oil for epilepsy, you will undoubtedly find the NuLeaf brand in it. Certified by USDA, the company has a six-years of experience in providing the purest, effective, and potent CBD products from farms in Colorado. Complete transparency in production is one of the main company’s values. The company follows federal guidelines in planting, growing, and processing their tincture weed plants. All of the products contain less than 0.3% of THC, which makes them completely non-psychoactive. The brand holds the key to keeping the best CBD strains for seizures and protect them from toxic substances.
- All-natural CBD
- CO2 extracted
- Third-party testing
- Lack of samples
NuLeaf Naturals offers a vast range of CBD oil goods both for people and pets. The company also provides a broad assortment of potencies to buy CBD oil for seizures from 240 mg, priced $38,50 to 2425 mg per $239. The highest strength product reaches 4850 mg and costs $439. On top of that, free shipping, all the way the USA seems to be a tempting offer. And, as a rule of common decency, the company guarantees total money back in case if you find yourself unsatisfied with the product or service. The company can also be proud of the possibility of abroad shipping, which is exceptionally seldom among representatives within this niche of services.
CBD oil affects calcium transmission in the organism by reducing it. As a result, excessive electrical brain activity suppressed. For people with epilepsy, it means the seizures are not as severe as they were before, and their frequency decreased.
Elixinol CBD Tinctures
Short Brand Review
Elixinol not only makes one of the best CBD oil for epilepsy accessible but also aims to educate a vast range of people about the benefits of CBD products in the health-care system. The company delivers CBD oil from organic hemp plants, protecting its healthy properties by extracting CO2. All of their tinctures are also USDA certified. Therefore, the company can provide organic certification. Elixinol enriches natural components with aloe oil, coconut oil, and other useful elements. In addition to that, you may choose between two delicious flavors natural and cinnamon, regarding your preferences.
- Pure composition
- No artificial additives
- Variety of flavors
- No abroad shipping – only within the US
As it goes with other brands, the price depends on the potency of the bottle and ranges from $29,99 per 300 mg to $249,99 per 3600 mg. If you purchase from the official site, you may get a special offer discount from 10% to 20%.
The company produces full-spectrum CBD strains with amino acids, omega fatty acids, protein, and glycosides, which affect our bodies holistically: improving neurotransmitters’ functions and boosting the immune system. The bottle equipped with easy to use marked dropper for accuracy so that you wouldn’t miss with a dosage. Gluten-free and vegan-friendly, it has all chances to be rated best CBD oil for epilepsy.
Fab CBD 1200 mg Premium CBD Oil Drops
Short Brand Review
What type of CBD is best for seizures? The first answer that comes to the mind is the one that is all-natural. Fab CBD designs pure CBD oil under all the necessary conditions – proper light, temperature, and moisture. The company is transparent about farming and producing its CBD goods. All the detailed descriptions you will find on the official web page of the brand. The products consist of whole-plant hemp extracts, with no GMO and zero pesticides. A trace amounts of hemp-derived THC less than 0.3%
- Full-spectrum CBD oil
- Laboratory tested and verified
- May be used as a food supplement
- Long shipping
- Takes some time before the effect
Fab CBD offers four potencies from 300 mg to 2400mg and the price ranges accordingly from $39 to $129. The official site provides free shipping within the US on purchases over $89.
CBD oil helps you coping with everyday stresses, gaining a sense of calm and, as a result, decreasing seizures. It’s convenient for sublingual use or as a food additive. Moreover, you may choose between five flavors: natural, citrus, berry, mint, and vanilla. It will last you a while to take the suggested dose a day.
Bluebird Botanicals 2000 mg Hemp Complete
Short Brand Review
Hemp Complete CBD Oil particularly contains steam-distilled CBD extract and organic extra virgin olive oil, which is why it is rated as the best CBD oil for refractory epilepsy. Instead of the CO2 extraction method, the company uses steam distillation. The heat effectively drags out ketones and terpenes – the nutrients of the weed plant. The official site of the brand is full of clarifications and encyclopedia notes for every component or the process of producing CBD oil.
- All-natural components
- Organically grown hemp
- 3rd-party Certificates of Analysis
- Paid delivery
- No abroad shipping
Depending on the potency, the prices vary from $15 to $160. Even though the shipping is paid, the official site offers a subscription program, which automatically delivers products on your schedule and saves you up to 15%. In addition to that, monthly, you get a chance to use a discount code to save even 30%.
In general, CBD oil helps to manage brain activity by influencing the electrical impulses of neurons system. As a result, you will handle with insomnia, which is a concomitant symptom for epileptic people. Calmness at daily tasks and work will help to reduce seizures and mitigate the consequences of ones.
What Stands Behind The Epilepsy?
Epilepsy is a chronic brain disease characterized by repeated unprovoked seizures with various clinical manifestations. During an epileptic attack, multiple disorders of a motor, sensory, mental, mental, and autonomic functions can be noted. These disorders are caused by excessive neuronal discharges in the gray matter of the cerebral cortex.
Conventionally, all forms of epilepsy can be divided into two broad groups: epilepsy with a hereditary genetic predisposition and acquired epilepsy. For the diagnosis of epilepsy, two points are essential: the development of repeated seizures and the development of spontaneous unprovoked seizures. The exception is reflex attacks of epilepsy. Classic examples of reflex seizures are characteristic of photosensitive epilepsy when a light stimulus can provoke an epileptic seizure.
It is necessary to distinguish between epilepsy as a disease and as a syndrome. Epilepsy is an independent chronic neurological disease. The epileptic syndrome is a manifestation of various diseases accompanied by convulsive tonic-clonic seizures, loss of consciousness, and other symptoms that can be triggered by external factors, such as high fever.
Most often, epilepsy begins in childhood. One of the main reasons for the development of the disease is a violation of the activity of genes responsible for the work of sodium, potassium, hydrogen, and chloride channels in the nerve cell. As a result of these deviations, the polarization of the membrane of the nerve cell is disrupted, the activity of neuroglia cells changes. As a result, neuronal cells sharply increase their activity. Thus, epilepsy can be caused by genetic changes that lead to increased activity of the nerve cell and surrounding cells – neuroglia cells. But there are other types of epilepsy that are associated with specific genes and have a monogenic inheritance. A particular gene and a specific problem related to impaired activity of this gene lead to the disease. But in most of these cases, epilepsy is polygenic, that is, a combination of changes in gene activity is necessary for its development, which leads to the phenomenon of hyper-excitability of the cerebral cortex and the development of epileptic seizures.
Youthful forms of epilepsy can also “benign”. Such types may not affect development and can be effectively controlled by antiepileptic drugs. In general, modern methods of therapy can effectively help patients in 60–70% of cases. The claim that epilepsy is incurable is a myth. The combination of drug treatment with surgical methods and neuromodulation in most cases can help even in difficult situations.
There are several approaches to the treatment of epilepsy: medicated and surgical methods and the use of neuromodulation. Often these methods are combined. In some forms of epilepsy, a special ketogenic diet is used. The mechanism of this diet is not fully understood. Still, it is understood that ketone bodies can trigger a series of biochemical processes, as a result of which epileptic discharges are suppressed.
In medicated therapy, a group of antiepileptic drugs – anticonvulsants are used. Neurosurgery is used in forms resistant to drug therapy, in the formation of a stable focus of epileptic activity in the brain.
Where Can I Buy CBD Oil For Epilepsy?
Now that you have found the answer to the question “What is the best CBD oil for epilepsy?” your next reasonable wonder would be of where you can purchase it. Undoubtedly, the best place to get CBD pills for epilepsy would be a certified medical store. Whether it will be a brick and mortar one or an e-commerce website, make sure it is licensed and approved. The modern market of the service offers a vast range of assortment: pills, spray, capsules, etc. But among other options, CBD oil seems preferable one, because you may use it not only as medication but also as a food additive, which certainly improves not only the therapeutic process but daily well-being as well. Before purchasing any of it, learn CBD oil for epilepsy review and coordinate with your doctor on how to use it.